Diagnostic Performance of 68Gallium Labelled Prostate-Specific Membrane Antigen Positron Emission Tomography/Computed Tomography and Magnetic Resonance Imaging for Staging the Prostate Cancer with Intermediate or High Risk Prior to Radical Prostatectomy: A Systematic Review and Meta-analysis
The World Journal of Men¡Çs Health 2020³â 38±Ç 2È£ p.208 ~ p.219
(Wu Hui) - Qingdao University Affiliated Hospital Department of Urology
(Xu Ting) - 971th Hospital of PLA Department of Geratology
(Wang Xiao) - Qingdao University Affiliated Hospital Department of Urology
(Yu Yong-Bo) - Qingdao University Affiliated Hospital Department of Urology
(Fan Zhong-Yuan) - Qingdao University Affiliated Hospital Department of Urology
(Li Dan-Xia) - Qingdao University Affiliated Hospital Department of Urology
(Luo Lei) - Qingdao University Affiliated Hospital Department of Urology
(Yang Xue-Cheng) - Qingdao University Affiliated Hospital Department of Urology
(Jiao Wei) - Qingdao University Affiliated Hospital Department of Urology
(Niu Hai-Tao) - Qingdao University Affiliated Hospital Department of Urology
Abstract
Purpose: To compare the diagnostic efficiency of 68Gallium labelled prostate-specific membrane antigen positron emission tomography (68Ga-PSMA PET) and magnetic resonance imaging (MRI) for staging the lymph node metastases (LNMs) in the prostate cancer.
Materials and Methods: A broad search of scientific databases including PubMed, EMBASE, Web of Science, Cochrane Database, and Chinese Biomedicine Literature Database (updated prior to November 1st, 2018) was conducted systematically by two reviewers. In this paper, we evaluated the methodological quality of each included article independently and performed a systematic review and meta-analysis to reveal the summary of the diagnostic performance of 68Ga-PSMA PET and MRI in properly identifying LNMs of intermediate- and/or high-risk prostate cancer.
Results: Thirteen eligible articles comprising 1,597 patients were included. For LNMs detection, the pooled sensitivity and specificity of 68Ga-PSMA PET were 0.65 (95% confidence interval [CI]: 0.49?0.79) and 0.94 (95% CI: 0.88?0.97), respectively, while the corresponding values of MRI were 0.41 (95% CI: 0.26?0.57) and 0.92 (95% CI: 0.86?0.95). The area under the symmetric receiver-operating characteristic (SROC) curve for 68Ga-PSMA PET and MRI were 0.92 and 0.83, respectively.
Conclusions: In intermediate- or high-risk pre-treatment prostate cancer, 68Ga-PSMA PET had a higher sensitivity and a slightly different specificity in probing the LNMs when comparing with MRI. Moreover, the area under the SROC curve indicated that 68Ga-PSMA PET was a more effective weapon for predicting the LNMs prior to radical surgery.
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Magnetic resonance imaging, Metastasis, Meta-analysis, Positron-emission tomography, Prostate cancer
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When comparing with MRI, 68Ga-PSMA PET had a higher sensitivity and a comparable specificity for staging the preoperative LNMs in the intermediate- and high-risk prostate cancer; In intermediate- or high-risk pre-treatment prostate cancer, 68Ga-PSMA PET had a higher sensitivity and a slightly different specificity in probing the LNMs when comparing with MRI.